The human epidermal growth factor receptor (HER/ErbB) family comprises four cell surface receptors-HER1 (epidermal growth factor receptor), HER2, HER3 and HER4. MRG002 has the potential to become one of the best HER2-targeting agents to address significant unmet medical needs in high- or medium-to-low HER2 expressing solid tumors. Featuring hyper-fucosylation of trastuzumab by design and clinically proven linker-payload, MRG002 exhibited reduced ADCC activity yet strong antitumor activity in trastuzumab- or T-DM1-resistant HER2-expressing PDX models.
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